This article concerns the design of Decision Support Systems (DSS) based on a Knowledge Discovery from Data (KDD) process. This process aims at generating a set of software modules; it is iterative and interactive For this reason, it is essential to us to take Human-Computer Interaction principles and models into account in the development of such systems. The interactive decisional system development is currently approached according to two antagonistic approaches. For the first approach, technology is fundamental; the second is "user-centered", placing the human actors in a central position. Although the first approach is still very present in companies, the current tendency "is user-centered ". In this context, we propose an approach which aims at integrating the stages of KDD process in a development model enriched under the human-computer interaction point of view, which is the U-model. Our application context is the fight against the nosocomial infections in the healthcare domain.